Pronunciation: al-PRAY-zoh-lam (also pronounced al-PRAZ-oh-lam)
Chemical Abstracts Service Registry Number: 28981-97-7
Formal Names: Alplax, Frontal, Solanax, Tafil, Trankimazin, Xanax, Xanor, Zotran
Type: Depressant (benzodiazepine class).
Federal Schedule Listing: Schedule IV (DEA no. 2882)
USA Availability: Prescription
Pregnancy Category: D

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Most polular benzodiapines drugs:

Xanax - generic name Alprazolam

Valium - generic name Diazepam

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Benzodiazepines comprise the most frequently prescribed subclass of antianxiety agents. These agents, first introduced in the early 1960s, quickly replaced the use of barbiturates as the pharmacological approach to anxiety. The popularity of these agents can be attributed to their generally quick onset of action and wider safety margin in overdose compared to the barbiturates. However, the potential of these agents to elicit physical dependence also quickly became apparent. In addition to the frequent use of these agents as anxiolytics, benzodiazepines are also commonly used for muscle tension, insomnia, status epilepticus (diazepam), myoclonic epilepsy (clonazepam), preoperative anesthesia, and alcohol withdrawal. Importantly, Ativan (lorazepam) is often used in the emergency room and inpatient setting to manage acute agitation in patients. Controlled studies involving Asians and Caucasians demonstrated significant pharmacokinetic differences involving use of the benzodiazepines (Ghoneim et al. 1981; Kumana et al. 1987). The volume of distribution of diazepam in these studies was found to be lower, and both serum diazepam and desmethyldiazepam levels were higher in Asian than in white physically and psychiatrically healthy volunteers. These differences became statistically insignificant, however, after controlling for ethnic differences in skinfold thickness and the ratio of actual to ideal body weight, suggesting that ethnic differences may be secondary to differences in the percentage of body fat.

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The focus of pharmacogenetic studies has largely been on those genes that encode enzymes responsible for the metabolism of medications. However, ethnic differences may also be affected by genes controlling the function and response of therapeutic targets. A well-established example of the difference that exists between different ethnic groups is the metabolism of alcohol. One of the enzymes responsible for the metabolism of alcohol is acetaldehyde dehydrogenase (ALDH), and 40%–50% of Asian subjects have a mutation that renders this enzyme inactive. The result is an uncomfortable “flushing” response, well known among many Asians even with a very small amount of alcohol (Agarwal and Goedde 1992; Yoshida 1993). It is now known that a mutation in a single nucleotide is responsible for the production of the inactive form of ALDH (Novoradovsky et al. 1995; Goedde et al. 1986).

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What is the difference between Xanax and Xanax Retard? Is it important for a patient taking 1.0 mg before going to sleep?

Action of Xanax comes into force in 1-2 hours and lasts during 16 hours. Xanax Retard as a rule is taken by 1mg in 24 hours.
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Xanax is a medication which belongs to the group of benzodiazepines used to treat depression and anxiety. Xanax has also other brand names such as: Xanor, Tafil, Niravam. Its generic name is Alprazolam.

In 1982 FDA approved it as a good preparation to treat GAD – Generalized Anxiety Disorder, panic disorder with or without agoraphobia, and anxiety that is associated with state of depression. (It should not be confused with treatment of depression alone).
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Some aspects of the psychopharmacologic effectiveness of Alprazolam (Xanax, Xanor) in a general somatic practice. Often occurrence of the anxiety and depression in the whole population and prevalence of these abnormalities in patients of a somatic type - define the urgency and practical meaning of search of the drugs with analeptic and anxiolytic actions, which meet such requirements as capacity and speed of the psychopharmacologic effect, safety and life quality as well. One of the medications of the kind, combining the effects mentioned above is Alprazolam (Xanax, Xanor). The aim of the investigation is a specification of psychopharmacologic effectiveness of the medication in a general somatic practice. Read the rest of this entry »

It is known that panic attacks are accompanied with agoraphobia. We may note at once that it is senselessly to escape the places where you had a panic attack. Such places may be lift, subway, market and big supermarket, electric train and so on. People begin to escape a transport mainly because it may be stuffy; they are pressed in a crowd and there may be a fear that they’ll feel bad and nobody will help them, that they will not be able to control the situation and leave this place in time, that the train may stop in the railway tunnel, they will lose consciousness and so on. As a matter of fact, the panic attack may happen anywhere, even in own flat. It is impossible to escape all the places where panic attack may start. Following this logic of escaping, the patients sometimes even do not leave their homes, at least, alone. Introducing the restrictions concerning movements as well as that places where panic attacks occurred, you deprive yourself of many opportunities and, finally, appear in a social isolation: it is impossible to agree to have more high-paid job, which is situated far away from home, it is impossible to visit your friends, theatres, exhibitions, etc. Read the rest of this entry »

1. If it is the first time you’ve had an attack, try to define the emotional factors which could provoke a strong feeling of anxiety. Find the connection between your feelings, state and antecedent events. Analyze the problem and try to solve it.
2. Try not to develop a limiting conduct even if your panic attack occurred on the street or in the transport. Keep on using a transport and have as active way of life as it is possible.
3. Having the first signs of the panic attack take some benzodiazepines, for example Xanax, Diazepam, Valium, Alprazolam or other. Bear this medication with yourself. After taking the medication, effect is felt in about 20-30 minutes. Such medications as Xanax may stop the attack in full or smooth away the symptoms. With a help of the medication you will stand the panic attack in a benign.

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Now I think that it will not be an exaggeration if I say that I am a person with a great experience of anxiety / panic disorder. The feeling, which now has its diagnosis, appeared about thirty years ago and I may say that the most amazing thing was the fact that it appeared so unexpectedly and without any reason that I hardly could guess what happened to me. I understood that my state of health was getting worse and worse but I even did not try to manage it as I did not realize that I had a disease and needed a consultation of professional doctors. Read the rest of this entry »