October 17th, 2008
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Generic Name: Tramadol
Brand name: Ultram, Ultram ER, Amadol, Tramadolor
Class of drug: Narcotic (opioid) analgesic.
Mechanism of action: Most likely produces analgesia by binding to opioid receptors. Also inhibits reuptake of norepinephrine and serotonin.
Indications/dosage/route: Oral only.
- Moderate to moderately severe pain
Adults: 50-100 mg q4-6h prn. Maximum: 400 mg/d.
Adjustment of dosage
- Kidney disease: Creatinine clearance <30 mL/min: 50-100 mg q12h. Maximum: 200 mg/d.
- Liver disease (cirrhosis): 50 mg q12h.
- Elderly: Maximum daily dose of 300 mg in patients >75 years.
- Pediatric: Safety and efficacy of tramadol have not been estab-
- lished in children <16 years. Read the rest of this entry »
